Interaction network among functional drug groups.

ABSTRACT:

Background

More attention has been being paid to combinatorial effects of drugs to treat complex diseases or to avoid adverse combinations of drug cocktail. Although drug interaction information has been increasingly accumulated, a novel approach like network-based method is needed to analyse that information systematically and intuitively

Results

Beyond focussing on drug-drug interactions, we examined interactions between functional drug groups. In this work, functional drug groups were defined based on the Anatomical Therapeutic Chemical (ATC) Classification System. We defined criteria whether two functional drug groups are related. Then we constructed the interaction network of drug groups. The resulting network provides intuitive interpretations. We further constructed a

SUBMITTER: Lee M 

PROVIDER: S-EPMC3852121 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature