Physiological and pharmacokinetic effects of oral 1,3-dimethylamylamine administration in men.

ABSTRACT:

Background

1,3-dimethylamylamine (DMAA) has been a component of dietary supplements and is also used within "party pills," often in conjunction with alcohol and other drugs. Ingestion of higher than recommended doses results in untoward effects including cerebral hemorrhage. To our knowledge, no studies have been conducted to determine both the pharmacokinetic profile and physiologic responses of DMAA.

Methods

Eight men reported to the lab in the morning following an overnight fast and received a single 25 mg oral dose of DMAA. Blood samples were collected before and through 24 hours post-DMAA ingestion and analyzed for plasma DMAA concentration using high-performance liquid chromatography-mass spectrometry. Resting heart rate, blood pressure, and body temperature was also m

SUBMITTER: Schilling BK 

PROVIDER: S-EPMC3852303 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature