Coupling between noise and plasticity in E. coli.

ABSTRACT: Expression levels of genes vary not only between different environmental conditions ("plasticity") but also between genetically identical cells in constant environment ("noise"). Intriguingly, these two measures of gene expression variability correlate positively with each other in yeast. This coupling was found to be particularly strong for genes with specific promoter architecture (TATA box and high nucleosome occupancy) but weak for genes in which high noise may be detrimental (e.g., essential genes), suggesting that noise-plasticity coupling is an evolvable trait in yeast and may constrain evolution of gene expression and promoter usage. Recently, similar genome-wide data on noise and plasticity have become available for Escherichia coli, providing the opportunity to study noise-plasti

SUBMITTER: Singh GP 

PROVIDER: S-EPMC3852374 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature