Mated progeny production is a biomarker of aging in Caenorhabditis elegans.

ABSTRACT: The relationships between reproduction and aging are important for understanding the mechanisms of aging and evaluating evolutionary theories of aging. To investigate the effects of progeny production on reproductive and somatic aging, we conducted longitudinal studies of Caenorhabditis elegans hermaphrodites. For mated wild-type animals that were not sperm limited and survived past the end of the reproductive period, high levels of cross-progeny production were positively correlated with delayed reproductive and somatic aging. In this group of animals, individuals that generated more cross progeny also reproduced and lived longer than individuals that generated fewer cross progeny. These results indicate that progeny production does not accelerate reproductive or somatic aging. This longi

SUBMITTER: Pickett CL 

PROVIDER: S-EPMC3852384 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature