Saccharomyces cerevisiae genes involved in survival of heat shock.

ABSTRACT: The heat-shock response in cells, involving increased transcription of a specific set of genes in response to a sudden increase in temperature, is a highly conserved biological response occurring in all organisms. Despite considerable attention to the processes activated during heat shock, less is known about the role of genes in survival of a sudden temperature increase. Saccharomyces cerevisiae genes involved in the maintenance of heat-shock resistance in exponential and stationary phase were identified by screening the homozygous diploid deletants in nonessential genes and the heterozygous diploid mutants in essential genes for survival after a sudden shift in temperature from 30 to 50°. More than a thousand genes were identified that led to altered sensitivity to heat shock, with littl

SUBMITTER: Jarolim S 

PROVIDER: S-EPMC3852394 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature