Ontology highlight
ABSTRACT:
SUBMITTER: Horikoshi N
PROVIDER: S-EPMC3852653 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Acta crystallographica. Section D, Biological crystallography 20131119 Pt 12
The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. However, no structural differences between H2A.Z.1 and H2A.Z.2 have been reported. In the present study, the crystal structures of nucleosomes containing human H2A.Z.1 and H2A.Z.2 were determined. The structures of the L1 loop regions were found to clearly differ between H2A.Z.1 and H2A.Z.2, alth ...[more]