NumbL is essential for Xenopus primary neurogenesis.

ABSTRACT:

Background

Members of the vertebrate Numb family of cell fate determinants serve multiple functions throughout early embryogenesis, including an essential role in the development of the nervous system. The Numb proteins interact with various partner proteins and correspondingly participate in multiple cellular activities, including inhibition of the Notch pathway.

Results

Here, we describe the expression characteristics of Numb and Numblike (NumbL) during Xenopus development and characterize the function of NumbL during primary neurogenesis. NumbL, in contrast to Numb, is expressed in the territories of primary neurogenesis and is positively regulated by the Neurogenin family of proneural transcription factors. Knockdown of NumbL afforded a complete loss of primary neurons a

SUBMITTER: Nieber F 

PROVIDER: S-EPMC3852787 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature