Whole genome methylation array analysis reveals new aspects in Balkan endemic nephropathy etiology.

ABSTRACT:

Background

Balkan endemic nephropathy (BEN) represents a chronic progressive interstitial nephritis in striking correlation with uroepithelial tumours of the upper urinary tract. The disease has endemic distribution in the Danube river regions in several Balkan countries.DNA methylation is a primary epigenetic modification that is involved in major processes such as cancer, genomic imprinting, gene silencing, etc. The significance of CpG island methylation status in normal development, cell differentiation and gene expression is widely recognized, although still stays poorly understood.

Methods

We performed whole genome DNA methylation array analysis on DNA pool samples from peripheral blood from 159 affected individuals and 170 healthy individuals. This technique allowed us

SUBMITTER: Staneva R 

PROVIDER: S-EPMC3852817 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature