Chemotherapy-induced hyaluronan production: a novel chemoresistance mechanism in ovarian cancer.

ABSTRACT:

Background

Hyaluronan (HA) an important component of the extracellular matrix, has been linked to tumor progression and drug resistance in several malignancies. However, limited data is available for ovarian cancer. This study investigated the role of hyaluronan (HA) and a potential link between the HA-CD44 pathway and membrane ATP binding cassette (ABC) transporter proteins in ovarian cancer chemoresistance.

Methods

We investigated the ability of HA to block the cytotoxic effects of the chemotherapy drug carboplatin, and to regulate the expression of ABC transporters in ovarian cancer cells. We also examined HA serum levels in ovarian cancer patients prior to and following chemotherapy and assessed its prognostic relevance.

Results

HA increased the survival of carbop

SUBMITTER: Ricciardelli C 

PROVIDER: S-EPMC3852938 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature