Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients.

ABSTRACT:

Background

Glatiramer acetate (GA) is a mixture of synthetic peptides used in the treatment of patients with relapsing-remitting multiple sclerosis (RRMS). The aim of this study was to investigate the effects of GA therapy on the gene expression of monocytes.

Methods

Monocytes were isolated from the peripheral blood of eight RRMS patients. The blood was obtained longitudinally before the start of GA therapy as well as after one day, one week, one month and two months. Gene expression was measured at the mRNA level by microarrays.

Results

More than 400 genes were identified as up-regulated or down-regulated in the course of therapy, and we analyzed their biological functions and regulatory interactions. Many of those genes are known to regulate lymphocyte activation an

SUBMITTER: Thamilarasan M 

PROVIDER: S-EPMC3852967 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature