Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence.

ABSTRACT: Despite a significant genetic contribution to alcohol dependence (AD), few AD-risk genes have been identified to date. In the current study, we aimed to integrate genome-wide association studies (GWASs) and human protein interaction networks to investigate whether a subnetwork of genes whose protein products interact with one another might collectively contribute to AD. By using two discovery GWAS data sets of the Study of Addiction: Genetics and Environment (SAGE) and the Collaborative Study on the Genetics of Alcoholism (COGA), we identified a subnetwork of 39 genes that not only was enriched for genes associated with AD, but also collectively associated with AD in both European Americans (p < 0.0001) and African Americans (p = 0.0008). We replicated the association of the gene subnetwor

SUBMITTER: Han S 

PROVIDER: S-EPMC3853414 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature