Psoriasis and cardiovascular risk factors: increased serum myeloperoxidase and corresponding immunocellular overexpression by Cd11b(+) CD68(+) macrophages in skin lesions.

ABSTRACT:

Background

Recent studies report independent associations between psoriasis, cardiovascular (CV) events and risk factors. Blood Myeloperoxidase (MPO) from activated myeloid cells is associated with CV risk mainly through lipid oxidation, induction of endothelial dysfunction and release of IL-12 from macrophages.

Objectives

To elucidate associations between psoriasis and conventional CV risk factors.

Methods

We performed a cross-sectional study of 100 psoriasis patients and 53 controls, group matched on age, gender and body mass index, to assess levels of MPO in serum, as well as immunohistochemical staining from psoriasis skin lesions, psoriasis uninvolved skin, and normal skin.

Results

Although the groups did not differ on waist circumference, glucose, cholest

SUBMITTER: Cao LY 

PROVIDER: S-EPMC3853421 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature