Common variation contributes to the genetic architecture of social communication traits.

ABSTRACT:

Background

Social communication difficulties represent an autistic trait that is highly heritable and persistent during the course of development. However, little is known about the underlying genetic architecture of this phenotype.

Methods

We performed a genome-wide association study on parent-reported social communication problems using items of the children's communication checklist (age 10 to 11 years) studying single and/or joint marker effects. Analyses were conducted in a large UK population-based birth cohort (Avon Longitudinal Study of Parents and their Children, ALSPAC, N = 5,584) and followed-up within a sample of children with comparable measures from Western Australia (RAINE, N = 1364).

Results

Two of our seven independent top signals (P-discovery <1.0E-0

SUBMITTER: St Pourcain B 

PROVIDER: S-EPMC3853437 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature