Case-control association analysis of dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males.

ABSTRACT:

Background

Brain imaging studies and knock-out animal models have derived substantial abetment for dopamine receptor (DR) subtypes as potential candidates in susceptibility to addictive disorders, including alcohol dependence (AD). Various association studies that compared the frequencies of alleles of the dopamine D1, D2, D3 and D4 receptor genes between alcohol dependent and control subjects have produced suggestive results, though some of them are discordant in nature. In the absence of genetic data from Indian population, we evaluated genetic association of three polymorphisms namely rs4532 in DRD1, rs6280 in DRD3 and 120 bp duplication in 1.2 kb upstream region of DRD4 with AD.

Methods

A total of 90 cases (alcohol dependent males) and 122 age and ethnicity matched healt

SUBMITTER: Prasad P 

PROVIDER: S-EPMC3853477 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature