HCN1 channels in cerebellar Purkinje cells promote late stages of learning and constrain synaptic inhibition.

ABSTRACT: Neural computations rely on ion channels that modify neuronal responses to synaptic inputs. While single cell recordings suggest diverse and neurone type-specific computational functions for HCN1 channels, their behavioural roles in any single neurone type are not clear. Using a battery of behavioural assays, including analysis of motor learning in vestibulo-ocular reflex and rotarod tests, we find that deletion of HCN1 channels from cerebellar Purkinje cells selectively impairs late stages of motor learning. Because deletion of HCN1 modifies only a subset of behaviours involving Purkinje cells, we asked whether the channel also has functional specificity at a cellular level. We find that HCN1 channels in cerebellar Purkinje cells reduce the duration of inhibitory synaptic responses but, i

SUBMITTER: Rinaldi A 

PROVIDER: S-EPMC3853504 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature