Derivatives of salarin A, salarin C and tulearin A--Fascaplysinopsis sp. metabolites.

ABSTRACT: Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

SUBMITTER: Zur LG 

PROVIDER: S-EPMC3853741 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature