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Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp.

ABSTRACT: A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Eunicellin 1 exhibited significant cytotoxicity toward the DLD-1 human colorectal adenocarcinoma cells.

SUBMITTER: Chen TH 

PROVIDER: S-EPMC3853747 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp.

Chen Tsung-Hung TH   Lu Mei-Chin MC   Chang Yu-Chia YC   Su Yin-Di YD   Chen Yu-Hsin YH   Lin Nai-Cheng NC   Fang Lee-Shing LS   Wu Yang-Chang YC   Sung Ping-Jyun PJ  

Marine drugs 20131114 11

A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Eunicellin 1 exhibited significant cytotoxicity toward the DLD-1 human colorectal adenocarcinoma cells. ...[more]

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