Secreted proteins from carotid endarterectomy: an untargeted approach to disclose molecular clues of plaque progression.

ABSTRACT:

Background

Atherosclerosis is the main cause of morbidity and mortality in Western countries and carotid plaque rupture is associated to acute events and responsible of 15-20% of all ischemic strokes. Several proteomics approaches have been up to now used to elucidate the molecular mechanisms involved in plaque formation as well as to identify markers of pathology severity for early diagnosis or target of therapy. The aim of this study was to characterize the plaque secretome. The advantage of this approach is that secretome mimics the in vivo condition and implies a reduced complexity compared to the whole tissue proteomics allowing the detection of under-represented potential biomarkers.

Methods

Secretomes from carotid endarterectomy specimens of 14 patients were analyzed

SUBMITTER: Rocchiccioli S 

PROVIDER: S-EPMC3853772 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature