Studying synaptic efficiency by post-hoc immunolabelling.

ABSTRACT:

Background

In terms of vesicular recycling, synaptic efficiency is a key determinant of the fidelity of synaptic transmission. The ability of a presynaptic terminal to reuse its vesicular content is thought to be a signature of synaptic maturity and this process depends on the activity of several proteins that govern exo/endocytosis. Upon stimulation, individual terminals in networks of cultured cerebellar granule neurons exhibit heterogeneous exocytic responses, which reflect the distinct states of maturity and plasticity intrinsic to individual synaptic terminals. This dynamic scenario serves as the substrate for processes such as scaling, plasticity and synaptic weight redistribution. Presynaptic strength has been associated with the activity of several types of proteins, includ

SUBMITTER: Ramirez-Franco J 

PROVIDER: S-EPMC3854067 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature