BMP-mediated specification of the erythroid lineage suppresses endothelial development in blood island precursors.

ABSTRACT: The developmental relationship between the blood and endothelial cell (EC) lineages remains unclear. In the extra-embryonic blood islands of birds and mammals, ECs and blood cells are closely intermixed, and blood island precursor cells in the primitive streak express many of the same molecular markers, leading to the suggestion that both lineages arise from a common precursor, called the hemangioblast. Cells within the blood island of Xenopus also coexpress predifferentiation markers of the blood and EC lineages. However, using multiple assays, we find that precursor cells in the Xenopus blood island do not normally differentiate into ECs, suggesting that classic hemangioblasts are rare or nonexistent in Xenopus. What prevents these precursor cells from developing into mature ECs? We have

SUBMITTER: Myers CT 

PROVIDER: S-EPMC3854112 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature