Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling.

ABSTRACT:

Background

Transforming growth factor-betas (TGF-betas), bone morphogenetic proteins (BMPs) and activins are important regulators of developmental cell growth and differentiation. Signaling by these factors is mediated chiefly by the Smad family of latent transcription factors.

Results

There are a large number of uncharacterized cDNA clones that code for novel proteins with homology to known signaling molecules. We have identified a novel molecule from the HUGE database that is related to a previously known molecule, AMSH (associated molecule with the SH3 domain of STAM), an adapter shown to be involved in BMP signaling. Both of these molecules contain a coiled-coil domain located within the amino-terminus region and a JAB (Domain in Jun kinase activation domain binding prot

SUBMITTER: Ibarrola N 

PROVIDER: S-EPMC385422 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature