Immunological and clinical consequences of splenectomy in a multiple sclerosis patient treated with natalizumab.

ABSTRACT:

Objective

Here we report a case of a splenectomized white woman with natalizumab-associated progressive multifocal leukoencephalopathy (PML), occurring as early as after 11 infusions and provide blood fluorescence-activated cell sorting (FACS) analyses before and after natalizumab treatment.

Design

This is a report of a single case with immunological studies.

Methods

Methods comprised neurologic examination, magnetic resonance imaging, and cerebrospinal fluid (CSF) studies as well as immune cell FACS analyses from blood.

Results

Diagnosis of PML was established after positive John Cunningham virus (JCV) DNA was detected in the CSF. An immune reconstitution inflammatory syndrome was treated with repeated cycles of steroid pulses and intravenous immunoglobulins.

SUBMITTER: Lee DH 

PROVIDER: S-EPMC3854515 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature