Identification of neoblast- and regeneration-specific miRNAs in the planarian Schmidtea mediterranea.

ABSTRACT: In recent years, the planarian Schmidtea mediterranea has emerged as a tractable model system to study stem cell biology and regeneration. MicroRNAs are small RNA species that control gene expression by modulating translational repression and mRNA stability and have been implicated in the regulation of various cellular processes. Though recent studies have identified several miRNAs in S. mediterranea, their expression in neoblast subpopulations and during regeneration has not been examined. Here, we identify several miRNAs whose expression is enriched in different neoblast subpopulations and in regenerating tissue at different time points in S. mediterranea. Some of these miRNAs were enriched within 3 h post-amputation and may, therefore, play a role in wound healing and/or neoblast migrat

SUBMITTER: Sasidharan V 

PROVIDER: S-EPMC3854530 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature