Activated platelet-rich plasma improves adipose-derived stem cell transplantation efficiency in injured articular cartilage.

ABSTRACT:

Introduction

Adipose-derived stem cells (ADSCs) have been isolated, expanded, and applied in the treatment of many diseases. ADSCs have also been used to treat injured articular cartilage. However, there is controversy regarding the treatment efficiency. We considered that ADSC transplantation with activated platelet-rich plasma (PRP) may improve injured articular cartilage compared with that of ADSC transplantation alone. In this study, we determined the role of PRP in ADSC transplantation to improve the treatment efficiency.

Methods

ADSCs were isolated and expanded from human adipose tissue. PRP was collected and activated from human peripheral blood. The effects of PRP were evaluated in vitro and in ADSC transplantation in vivo. In vitro, the effects of PRP on ADSC prolif

SUBMITTER: Van Pham P 

PROVIDER: S-EPMC3854675 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature