B-type natriuretic peptides and mortality after stroke: a systematic review and meta-analysis.

ABSTRACT:

Objective

To measure the association of B-type natriuretic peptide (BNP) and N-terminal fragment of BNP (NT-proBNP) with all-cause mortality after stroke, and to evaluate the additional predictive value of BNP/NT-proBNP over clinical information.

Methods

Suitable studies for meta-analysis were found by searching MEDLINE and EMBASE databases until October 26, 2012. Weighted mean differences measured effect size; meta-regression and publication bias were assessed. Individual participant data were used to estimate effects by logistic regression and to evaluate BNP/NT-proBNP additional predictive value by area under the receiver operating characteristic curves, and integrated discrimination improvement and categorical net reclassification improvement indexes.

Results

Lite

SUBMITTER: Garcia-Berrocoso T 

PROVIDER: S-EPMC3854833 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature