Adipose-derived stem cells improved mouse ovary function after chemotherapy-induced ovary failure.

ABSTRACT:

Introduction

Young patients receiving chemotherapy occasionally face infertility and premature ovarian failure (POF). Numerous investigations reported that adipose-derived stem cells (ADSCs) transplantation could ameliorate the structure and function of injured tissues. The aim of this study was to explore the therapeutic efficacy of ADSC transplantation for chemotherapy-induced ovarian damage.

Methods

Female mice were injected intraperitoneally with 50 mg/kg cyclophosphamide (CTX). After 15 consecutive days of injection, ADSCs were transplanted either directly into bilateral ovaries or via intravenous injection, and the ovaries were excised after either 1 week or 1 month of treatment. The follicles were counted and categorized, and ovarian histologic sections were stained f

SUBMITTER: Sun M 

PROVIDER: S-EPMC3854877 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature