Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodents.

ABSTRACT: The contribution of regulatory versus protein change to adaptive evolution has long been controversial. In principle, the rate and strength of adaptation within functional genetic elements can be quantified on the basis of an excess of nucleotide substitutions between species compared to the neutral expectation or from effects of recent substitutions on nucleotide diversity at linked sites. Here, we infer the nature of selective forces acting in proteins, their UTRs and conserved noncoding elements (CNEs) using genome-wide patterns of diversity in wild house mice and divergence to related species. By applying an extension of the McDonald-Kreitman test, we infer that adaptive substitutions are widespread in protein-coding genes, UTRs and CNEs, and we estimate that there are at least four ti

SUBMITTER: Halligan DL 

PROVIDER: S-EPMC3854965 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature