Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant.

ABSTRACT:

Background

Perfluorooctanoic acid (PFOA) is a synthetic chemical ubiquitous in the serum of U.S. residents. It causes liver, testicular, and pancreatic tumors in rats. Human studies are sparse.

Objective

We examined cancer incidence in Mid-Ohio Valley residents exposed to PFOA in drinking water due to chemical plant emissions.

Methods

The cohort consisted of adult community residents who resided in contaminated water districts or worked at a local chemical plant. Most participated in a 2005-2006 baseline survey in which serum PFOA was measured. We interviewed the cohort in 2008-2011 to obtain further medical history. Retrospective yearly PFOA serum concentrations were estimated for each participant from 1952 through 2011. Self-reported cancers were validated through m

SUBMITTER: Barry V 

PROVIDER: S-EPMC3855514 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature