Primary prevention of diabetic retinopathy with fibrates: a retrospective, matched cohort study.

ABSTRACT:

Objectives

To compare the progression of diabetic retinopathy (DR) in people with type 2 diabetes treated with fibrates with that of non-exposed controls.

Design

Retrospective, matched cohort study.

Setting

UK Clinical Practice Research Datalink (CPRD).

Participants

5038 people with type 2 diabetes with a history of fibrate exposure but without evidence of DR were identified. Three thousand one hundred and seventy-six (63%) people could be randomly matched to one non-exposed control; of these, 2599 (81.8%) were matched without any missing blood pressure or glycated haemoglobin (HbA1c) values.

Main outcome measures

The primary endpoint was first recorded DR with a secondary endpoint of all-cause mortality or first DR. Time to clinical endpoints was compar

SUBMITTER: Morgan CL 

PROVIDER: S-EPMC3855563 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature