Intestinal alkaline phosphatase prevents antibiotic-induced susceptibility to enteric pathogens.

ABSTRACT:

Objective

To determine the efficacy of oral supplementation of the gut enzyme intestinal alkaline phosphatase (IAP) in preventing antibiotic-associated infections from Salmonella enterica serovar Typhimurium (S. Typhimurium) and Clostridium difficile.

Background

The intestinal microbiota plays a pivotal role in human health and well-being. Antibiotics inherently cause dysbiosis, an imbalance in the number and composition of intestinal commensal bacteria, which leads to susceptibility to opportunistic bacterial infections. Previously, we have shown that IAP preserves the normal homeostasis of intestinal microbiota and that oral supplementation with calf IAP (cIAP) rapidly restores the normal gut flora. We hypothesized that oral IAP supplementation would protect against antibi

SUBMITTER: Alam SN 

PROVIDER: S-EPMC3855644 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature