Immunological and virological benefits resulted from short-course treatment during primary HIV infection: a meta-analysis.

ABSTRACT:

Objectives

To assess the potential immunological and virological effects that result from short-course antiretroviral treatment during primary HIV infection (PHI). And to investigate whether treatment initiation time, treatment duration and follow-up time after treatment interruption would affect these post-treatment immunovirological outcomes.

Methods

We systematically searched PubMed, Cochrane Library (to September 2013) and retrieved conference abstracts for studies regarding effects of early treatment during PHI on CD4 count and viral load (VL). Using the method of calculating weighted mean differences with Stata11.0, we conducted meta-analyses on the effect of early treatment on CD4 count and VL. Then we performed subgroup analyses by follow-up time after treatment inte

SUBMITTER: Chen J 

PROVIDER: S-EPMC3855754 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature