Modulation of malaria infection in Anopheles gambiae mosquitoes exposed to natural midgut bacteria.

ABSTRACT: The development of Plasmodium falciparum within the Anopheles gambiae mosquito relies on complex vector-parasite interactions, however the resident midgut microbiota also plays an important role in mediating parasite infection. In natural conditions, the mosquito microbial flora is diverse, composed of commensal and symbiotic bacteria. We report here the isolation of culturable midgut bacteria from mosquitoes collected in the field in Cameroon and their identification based on the 16S rRNA gene sequencing. We next measured the effect of selected natural bacterial isolates on Plasmodium falciparum infection prevalence and intensity over multiple infectious feedings and found that the bacteria significantly reduced the prevalence and intensity of infection. These results contrast with our pr

SUBMITTER: Tchioffo MT 

PROVIDER: S-EPMC3855763 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature