The association of parity with osteoarthritis and knee replacement in the multicenter osteoarthritis study.

ABSTRACT:

Objective

We evaluated the association of parity to both risk of knee replacement (KR) and knee osteoarthritis (OA).

Design

The NIH-funded Multicenter Osteoarthritis Study (MOST) is a longitudinal observational study of persons age 50-79 years with either symptomatic knee OA or at elevated risk of disease. Baseline and 30-month knee radiographic OA (ROA) was defined as Kellgren/Lawrence (K/L) grade ≥2 or KR. Women were grouped based by number of births: 0; 1 (reference group); 2; 3; 4; and 5 or more. We examined the relation of parity to the incidence over 30 months of ROA and KR using a Poisson regression model. Generalized estimating equations (GEE) were used to control for correlation between two knees within a subject. We adjusted for age, BMI, race, education, occupatio

SUBMITTER: Wise BL 

PROVIDER: S-EPMC3855897 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature