Association of genetic variants of BMP4 with type 2 diabetes mellitus and clinical traits in a Chinese Han population.

ABSTRACT: BMP4 is one of the transforming growth factor- β superfamily, which can participate in adipogenesis. Gene encoding BMP4 is acknowledged as a convincing candidate that may contribute to both glucose and lipid metabolism. In this paper, we aimed to test the impacts of BMP4 variants on type 2 diabetes in a large sample of Chinese population. We genotyped 10 tagging single nucleotide polymorphisms within the BMP4 region in 6822 participants and acquired detailed clinical investigations and biochemistry measurements. We found that BMP4 rs8014363 showed nominal association towards type 2 diabetes, with the T allele conferring a high risk of type 2 diabetes (OR = 1.108, 95%CI 0.999-1.229, P = 0.051 for allele; OR = 1.110, 95%CI 1.000-1.231, P = 0.050 for genotype), but it was no longer statistica

SUBMITTER: Tang S 

PROVIDER: S-EPMC3855940 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature