Improving the AJCC/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade.

ABSTRACT:

Purpose

Though histological grade is known to have a major prognostic impact in metastatic mucinous appendiceal adenocarcinomas, the prognostic impact of grade in localized disease, and the validity of the American Joint Committee on Cancer AJCC Staging Manual 7th edition's decision to combine moderately and poorly differentiated mucinous adenocarcinomas into a single mucinous high-grade category, is not known.

Methods

Patients with adenocarcinoma of the appendix diagnosed between 1988 and 2007 were identified from the SEER database. Cancer-specific survival (CSS) stratified by histological subtype, stage, and grade was calculated, and Cox proportional hazards regression analyses were performed.

Results

We analyzed a total of 2469 appendiceal adenocarcinomas, of which

SUBMITTER: Overman MJ 

PROVIDER: S-EPMC3855996 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature