Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers.

ABSTRACT: Molecular etiology of thyroid cancers has been widely studied, and several molecular alterations have been identified mainly associated with follicular and papillary histotypes. However, the molecular bases of the complex pathogenesis of thyroid carcinomas remain poorly understood. HOX genes regulate normal embryonic development, cell differentiation and other critical processes in eukaryotic cell life. Several studies have shown that HOX genes play a role in neoplastic transformation of several human tissues. In particular, the genes belonging to HOX paralogous group 13 seem to hold a relevant role in both tumor development and progression. We have identified a significant prognostic role of HOX D13 in pancreatic cancer and we have recently showed the strong and progressive over-expressio

SUBMITTER: Cantile M 

PROVIDER: S-EPMC3856031 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature