Systems biology approach to the dissection of the complexity of regulatory networks in the S. scrofa cardiocirculatory system.

ABSTRACT: Genome-wide experiments are routinely used to increase the understanding of the biological processes involved in the development and maintenance of a variety of pathologies. Although the technical feasibility of this type of experiment has improved in recent years, data analysis remains challenging. In this context, gene set analysis has emerged as a fundamental tool for the interpretation of the results. Here, we review strategies used in the gene set approach, and using datasets for the pig cardiocirculatory system as a case study, we demonstrate how the use of a combination of these strategies can enhance the interpretation of results. Gene set analyses are able to distinguish vessels from the heart and arteries from veins in a manner that is consistent with the different cellular compo

SUBMITTER: Martini P 

PROVIDER: S-EPMC3856112 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature