Brainstem aminergic nuclei and late-life depressive symptoms.

ABSTRACT:

Importance

The neurobiologic basis of late-life depressive symptoms is not well understood.

Objective

To test the hypothesis that neurodegeneration and neuronal density in brainstem aminergic nuclei are related to late-life depressive symptoms. DESIGN, SETTING, PARTICIPANTS, AND EXPOSURE: Longitudinal clinicopathological cohort study at residences of participants in the Chicago, Illinois, metropolitan area. Participants included 124 older persons without dementia in the Rush Memory and Aging Project who had annual evaluations for a mean (SD) of 5.7 (2.8) years, died, and underwent a postmortem neuropathological examination that provided estimates of the densities of Lewy bodies, neurofibrillary tangles, and aminergic neurons in the locus ceruleus, dorsal raphe nucleus, subst

SUBMITTER: Wilson RS 

PROVIDER: S-EPMC3856195 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature