Lipidomic mass spectrometry and its application in neuroscience.

ABSTRACT: Central and peripheral nervous systems are lipid rich tissues. Lipids, in the context of lipid-protein complexes, surround neurons and provide electrical insulation for transmission of signals allowing neurons to remain embedded within a conducting environment. Lipids play a key role in vesicle formation and fusion in synapses. They provide means of rapid signaling, cell motility and migration for astrocytes and other cell types that surround and play supporting roles neurons. Unlike many other signaling molecules, lipids are capable of multiple signaling events based on the different fragments generated from a single precursor during each event. Lipidomics, until recently suffered from two major disadvantages: (1) level of expertise required an overwhelming amount of chemical detail to co

SUBMITTER: Enriquez-Algeciras M 

PROVIDER: S-EPMC3856305 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature