Ontology highlight
ABSTRACT:
SUBMITTER: Thiele I
PROVIDER: S-EPMC3856361 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Nature biotechnology 20130303 5
Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ∼2× more reactions and ∼1.7× more unique metabolites. Using Recon 2 we predicte ...[more]