Diet-induced obesity: dopamine transporter function, impulsivity and motivation.

ABSTRACT:

Objective

A rat model of diet-induced obesity (DIO) was used to determine dopamine transporter (DAT) function, impulsivity and motivation as neurobehavioral outcomes and predictors of obesity.

Design

To evaluate neurobehavioral alterations following the development of DIO induced by an 8-week high-fat diet (HF) exposure, striatal D2-receptor density, DAT function and expression, extracellular dopamine concentrations, impulsivity, and motivation for high- and low-fat reinforcers were determined. To determine predictors of DIO, neurobehavioral antecedents including impulsivity, motivation for high-fat reinforcers, DAT function and extracellular dopamine were evaluated before the 8-week HF exposure.

Methods

Striatal D2-receptor density was determined by in vitro kinetic

SUBMITTER: Narayanaswami V 

PROVIDER: S-EPMC3856583 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature