The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.

ABSTRACT:

Background

The members of MRE11/RAD50/NBN (MRN) protein complex participates in DNA double-strand break repair and DNA-damage checkpoint activation. We have previously shown that the p.I171V NBN gene mutation may contribute to the development of laryngeal cancer. This study tested the hypothesis that variants of the MRE11 and RAD50 genes, previously described as cancer risk factors, predispose to increased susceptibility to head and neck cancer.

Findings

In this study we analyzed the RAD50 and MRE11 genes in 358 patients: 175 with a single laryngeal cancer (LC), 115 with multiple primary tumors but one malignancy (primary or second) localized in the larynx (MPT-LC), 68 patients with multiple primary tumors localized in the head or neck (MPT) and 506 controls. No carriers of

SUBMITTER: Ziolkowska-Suchanek I 

PROVIDER: S-EPMC3856607 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature