Synthesis of cyclic guanidines via Pd-catalyzed alkene carboamination.

ABSTRACT: A new approach to the synthesis of substituted 5-membered cyclic guanidines is described. Palladium-catalyzed alkene carboamination reactions between acyclic N-allyl guanidines and aryl or alkenyl halides provide these products in good yield. This method allows access to a number of different cyclic guanidine derivatives in only two steps from readily available allylic amines.

SUBMITTER: Zavesky BP 

PROVIDER: S-EPMC3857308 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature