Diagnosing developmental dyscalculia on the basis of reliable single case FMRI methods: promises and limitations.

ABSTRACT: FMRI-studies are mostly based on a group study approach, either analyzing one group or comparing multiple groups, or on approaches that correlate brain activation with clinically relevant criteria or behavioral measures. In this study we investigate the potential of fMRI-techniques focusing on individual differences in brain activation within a test-retest reliability context. We employ a single-case analysis approach, which contrasts dyscalculic children with a control group of typically developing children. In a second step, a support-vector machine analysis and cluster analysis techniques served to investigate similarities in multivariate brain activation patterns. Children were confronted with a non-symbolic number comparison and a non-symbolic exact calculation task during fMRI acquis

SUBMITTER: Dinkel PJ 

PROVIDER: S-EPMC3857322 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature