Ontology highlight
ABSTRACT:
SUBMITTER: Ge RG
PROVIDER: S-EPMC3857443 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
World journal of gastroenterology 20131201 45
Helicobacter pylori (H. pylori) is a common human pathogen responsible for various gastric diseases. This bacterium relies on the production of urease and hydrogenase to inhabit the acidic environment of the stomach. Nickel is an essential cofactor for urease and hydrogenase. H. pylori has to uptake sufficient nickel ions for the maturation of urease, and on the other way, to prevent the toxic effects of excessive nickel ions. Therefore, H. pylori has to strike a delicate balance between the imp ...[more]