Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs.

ABSTRACT: Post-transcriptional control of gene expression is mediated by the interaction of RNA-binding proteins with their cognate mRNAs that specifically regulate their stability, localization and translation. mRNA-binding proteins are multifunctional and it has been proposed therefore that a combinatorial RNA-binding protein code exists that allows specific protein sub-complexes to control cytoplasmic gene expression under a range of pathophysiological conditions. We show that polypyrimidine tract-binding protein (PTB) is central to one such complex that forms in apoptotic cells. Thus, during apoptosis initiated by TNF-related apoptosis inducing ligand there is a change in the repertoire of RNA-binding proteins with which PTB interacts. We show that altering the cellular levels of PTB and its bin

SUBMITTER: King HA 

PROVIDER: S-EPMC3857619 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature