Transient impact of spike on theta rhythm in temporal lobe epilepsy.

ABSTRACT: Epileptic spike is an indicator of hyper-excitability and hyper-synchrony of neural networks. While cognitive deficit in epilepsy is a common observation, how spikes transiently influence brain oscillations, especially those essential for cognitive functions, remains obscure. Here we aimed to quantify the transient impacts of sporadic spikes on theta oscillations and investigate how such impacts may evolve during epileptogenesis. Longitudinal depth EEG data were recorded in the CA1 area of pilocarpine temporal lobe epilepsy (TLE) rat models. Phase stability, a measure of synchrony, and theta power were estimated around spikes as well as in the protracted spike-free periods (FP) at least 1h after spike bursts. We found that the change in theta power did not correlate with the change in phas

SUBMITTER: Ge M 

PROVIDER: S-EPMC3857724 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature