Reverse engineering the neuroblastoma regulatory network uncovers MAX as one of the master regulators of tumor progression.

ABSTRACT: Neuroblastoma is the most common extracranial tumor and a major cause of infant cancer mortality worldwide. Despite its importance, little is known about its molecular mechanisms. A striking feature of this tumor is its clinical heterogeneity. Possible outcomes range from aggressive invasion to other tissues, causing patient death, to spontaneous disease regression or differentiation into benign ganglioneuromas. Several efforts have been made in order to find tumor progression markers. In this work, we have reconstructed the neuroblastoma regulatory network using an information-theoretic approach in order to find genes involved in tumor progression and that could be used as outcome predictors or as therapeutic targets. We have queried the reconstructed neuroblastoma regulatory network usin

SUBMITTER: Albanus RD 

PROVIDER: S-EPMC3857773 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature