Lumican and versican are associated with good outcome in stage II and III colon cancer.

ABSTRACT:

Background

Tumor stroma plays an important role in the progression and metastasis of colon cancer. The glycoproteins versican and lumican are overexpressed in colon carcinomas and are associated with the formation of tumor stroma. The aim of the present study was to investigate the potential prognostic value of versican and lumican expression in the epithelial and stromal compartment of Union for International Cancer Control (UICC) stage II and III colon cancer.

Methods

Clinicopathological data and tissue samples were collected from stage II (n = 226) and stage III (n = 160) colon cancer patients. Tissue microarrays were constructed with cores taken from both the center and the periphery of the tumor. These were immunohistochemically stained for lumican and versican. Express

SUBMITTER: de Wit M 

PROVIDER: S-EPMC3857876 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature