Structure-function relationship of working memory activity with hippocampal and prefrontal cortex volumes.

ABSTRACT: A rapidly increasing number of studies are quantifying the system-level network architecture of the human brain based on structural-to-structural and functional-to-functional relationships. However, a largely unexplored area is the nature and existence of "cross-modal" structural-functional relationships, in which, for example, the volume (or other morphological property) of one brain region is related to the functional response to a given task either in that same brain region, or another brain region. The present study investigated whether the gray matter volume of a selected group of structures (superior, middle, and inferior frontal gyri, thalamus, and hippocampus) was correlated with the fMRI response to a working memory task, within a mask of regions previously identified as involved

SUBMITTER: Harms MP 

PROVIDER: S-EPMC3858000 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature